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Common manifestations include: Haematological symptoms : Fatigue, weakness, pallor, and shortness of breath due to anaemia Neurological symptoms : Paraesthesia (pins and needles) in hands and feet, numbness, difficulty walking, balance problems, and memory disturbance Psychological symptoms : Depression, irritability, confusion, and in severe cases, psychosis Oral symptoms : Glossitis (sore, red tongue), mouth ulcers General symptoms : Loss of appetite, weight loss, diarrhoea Neurological complications can become irreversible if left untreated , particularly subacute combined degeneration of the spinal cord, which affects the dorsal and lateral columns

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And they cant go past CHEK Level Two without case histories

Studies have shown that IGF-1 also helps reduce body fat by increasing fat metabolism

Conclusion This review summarized the recent development of CD-related systems including CD derivatives and their supramolecular assemblies, which provide versatile platforms and useful properties in the construction of supramolecular materials by forming the inclusion complexes